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Pravadoline

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Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase.1 Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 μM in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice).
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Pravadoline

Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase.1 Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 μM in mouse mind microsomes) and shows antinociceptive exercise (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice).1 In distinction to NSAIDs, pravadoline inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 μM), an impact much like that which is produced by opioid analgesics, but just isn’t attenuated by the opioid receptor antagonist, naloxone.1 Pravadoline doesn’t produce gastrointestinal irritation following acute or continual administration to rodents.1

CAS Quantity:92623-83-1
Chemical and bodily information
Components C23H26N2O3
Molar mass 378.46 g/mo

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JWH-073

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