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Methylone (also known as “3,4-methylenedioxy-N-methylcathinone”, “MDMC”, “βk-MDMA” and by the slang term “M1”) is an empathogen and stimulant psychoactive drug. It is a member of the substituted amphetamine, substituted cathinone, and substituted methylenedioxyphenethylamine classes. buy methylone USA, methylone Erowid, kopen, tructure, legal, Australia, methylone vs mephedrone, methylone structure
Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone. The only structural difference of methylone with respect to MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the β position of the phenethylamine core, forming a ketone group.
Methylone was first synthesized by the chemists Peyton Jacob III and Alexander Shulgin in 1996 for potential use as an antidepressant.
Methylone has been sold for recreational use, taking advantage of the absence of legal prohibition of this compound in many countries.
Resemblance to MDMA
See also: MDMA
Structural similarities between some amphetamine-like stimulants and their 3,4-methylenedioxy- derivatives.
Left: amphetamine, methamphetamine, and methcathinone.
Right: MDA, MDMA, and methylone
Methylone substitutes for MDMA in rats trained to discriminate MDMA from saline. Methylone does not substitute for amphetamine or for the hallucinogenic DOM in animals trained to discriminate between these drugs and saline.
Further, also in common with MDMA, methylone acts on monoaminergic systems. buy methylone USA, methylone Erowid, kopen, tructure, legal, Australia, methylone vs mephedrone
In vitro, methylone has one-third the potency of MDMA at inhibiting platelet serotonin accumulation and about the same in its inhibiting effects on the dopamine and noradrenaline transporters.
In spite of these behavioral and pharmacological similarities between methylone and MDMA, the observed subjective effects of both drugs are not completely identical. Alexander Shulgin wrote of the former:
“[Methylone] has almost the same potency as MDMA, but it does not produce the same effects. It has an almost antidepressant action, pleasant and positive, but not the unique magic of MDMA.”
Methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine.
In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine and dopamine transporters is similar. methylone structure. Isopropylphenidate
Notably, methylone’s affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x slower than that of MDMA. buy methylone USA, methylone Erowid, kopen, tructure, legal, Australia, methylone vs mephedrone.4F-MPH
The results of these differences in pharmacology relative to MDMA are that methylone is less potent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic, and behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine; however, methylone has relatively robust releasing capabilities, perhaps due to its ability to phosphorylate the monoamine transporters being similar in potency relative to MDMA. Benzylpiperazine buy
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